Research and testing of ingredients (licorice)
THE SUMMARY OF RESEARCH conducted by the University of Padua: Cortisol distributes and deposits fat, while its function depends on the activity of 11 beta-Hydroxysteroid dehydrogenase. The glycyrrhetinic acid, the active principle of the “sweet root” (licorice), blocks 11 beta-Hydroxysteroid dehydrogenase I and thus the content of cortisol.
“The cream consisting of glycyrrhetinic acids was tested by applying it to the thighs. Eighteen healthy women (aged 20-33 years) with normal BFI (Body Fat Index) were randomly selected for testing the cream in the area of thighs. The cream with 2.5% of glycyrrhetinic acids (n = 9) and placebo cream (n = 9) were used. The measurements on their thighs were performed before and after 1 month of application. Circumference and thickness of surface fat layer on thighs were significantly reduced in 9 cases referred to the cream with licorice. No changes in blood pressure and activities of renin in plasma were detected.”
“The effect of glycyrrhetinic acid (licorice) on the thickness of subcutaneous fat is probably related to the block of 11 beta-Hydroxysteroid dehydrogenase I at the level of fat cells. Thus we assume that the glycyrrhetinic acid (licorice) is efficient in reducing unwanted local accumulation of fat.”
SOURCE: Armanini D1, Nacamulli D, Francini – Pesenti F, Battagin G, Ragazzi E, Fiore C.
Department of Medical and Surgical Science – endocrinology, University of Padua, Via Ospedale 105, 35100 Padua, Italy.
Link to the research: http://www.ncbi.nlm.nih.gov/pubmed/15894038